The 11th ENCALS (European Network for the Cure of ALS) Meeting was held in Sheffield, United Kingdom from Friday 31st May to Sunday 2nd June 2013. Investigators in ALS research presented their work, covering a range of topics including genetics, patient prognosis, diagnosis and therapy. From the Irish ALS research group, talks were given by Kevin Kenna (“The frequencies of ALS gene variants: Evidence of oligogenic aetiology and heterogeneity across Europe.”) and Dr. Marwa Elamin (“Predicting prognosis in ALS patients: A data-led approach.”). Research was also presented by Dr. Peter Bede, Dr.Russell McLaughlin, Dr. Paramesh Iyer and Kevin Kenna in the form of posters.